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KMID : 1140120080130040330
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Cancer Prevention Research
2008 Volume.13 No. 4 p.330 ~ p.335
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Abstract
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Omega-3, a polyunsaturated fatty acid, is essential fatty acids necessary for human health against cardiovascular disease, inflammation, and cancer. In the present study, we investigated the effects of omega-3-rich harp seal oil (HSO) on the production of the proinflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) in mice. The culture supernatants of splenocytes exposed with HSO alone or HSO plus lipopolysaccharide (LPS) were harvested to assay TNF-α, IL-1β, and IL-6 production. Also, sera from the mice ip-injected with HSO alone or LPS plus HSO were assayed for the same cytokines. The TNF-α, IL-1β, and IL-6 from mice splenocytes exposed with HSO were decreased compared to dimethylsulfoxide (DMSO) control. The TNF-α and IL-1β in the culture supernatants from mice splenocytes exposed with LPS＋HSO were lower than those of the groups exposed with LPS alone. The TNF-α and IL-6 in the sera from mice injected with LPS＋HSO were lower than those of the groups injected with LPS only. These findings demonstrate that omega-3-rich harp seal oil downregulates the production of the proinflammatory cytokines such as TNF-α, IL-1β, and IL-6. These results show the probability of its usefulness for antiinflammatory effects if more research results were accumulated.
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KEYWORD
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Harp seal oil, Inflammation, TNF-α, IL-1β, IL-6, Mice
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